“Pain resolution is an active process that requires neutrophil activation.”
“Inflammation is painful, but this inflammation is needed for our body to resolve pain,” says Diatchenko. Without any anti-inflammatory drug treatment, the animals also experienced longer-term pain if their neutrophils were killed by injections of an antibody. This suggests that some inflammatory cells can help people overcome their pain – a process that might be disrupted by anti-inflammatory drugs.ĭiatchenko’s team also found that in mice given a back injury, treatment with anti-inflammatories such as dexamethasone and diclofenac relieved their pain in the short term, but led to more pain longer term. In those whose pain subsided over the next three months, one type of inflammatory immune cell – the neutrophils – showed higher levels of activity than in people whose pain persisted.
Read more: The back pain epidemic: Why popular treatments are making it worse
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